Lab Resources

This page is used for documenting key online resources used within the lab. Currently just a brief table, but expect future extensions as we develop and formalize lab protocols and techiques:

Key Resources	Description
ENSEMBL, GenBank	Genomics resources used to characterize DNA sequences and genomic context of genes affected by polyglutamine expansion between different species.
GEO, ArrayExpress, HDBase	Transcriptomics resources containing extensive experimental data on mRNA expression levels for polyglutamine expansion diseases. These include both human studies across different tissues (e.g.GSE3790 - brain, GDS1331 - peripheral blood, GSE8762 - lymphocytes, muscle), in addition to animal studies (GSE10263 - R6/2, Hdh4/Q80, CHL2 mice).
Proteomics Data	Proteomics databases are in their infancy compared to transcriptomics. Proteomics data for polyglutamine diseases is generally only available from original literature such as: Mochel F, Charles P, Seguin F, Barritault J, Coussieu C, et al. (2007) Early Energy Deficit in Huntington Disease: Identification of a Plasma Biomarker Traceable during Disease Progression. PLoS ONE 2(7): e647.
Metabolomics Data	In a similar way to proteomics data, we generally have to go to original sources to obtain metabolomics data for polyglutamine diseases such as: Tsang, T.M., Woodman, B., Mcloughlin, G.A., Griffin, J.L., Tabrizi, S.J., Bates, G.P., and Holmes, E. (2006) Metabolic Characterization of the R6/2 Transgenic Mouse Model of Huntington's Disease by High-Resolution MAS 1H NMR Spectroscopy. J. Proteome Res., 5, 3, 483 - 492.
Reactome, KEGG	Biological pathway resources used to integrate within and between different levels of high-throughput data above.
OMIM	Human disease database that provides a wealth of information about polyglutamine and other amyloid diseases.

This page last modified 14 March, 2008 by Kevin Bryson

"We build too many walls and not enough bridges" (Isaac Newton 1643-1727)