Speaker: Teresa Correia
UCL Contact: Dominique Drai (Visitors from outside UCL please email in advance).
Date/Time: 15 Jan 14, 13:00 - 14:00
Optical imaging modalities use near-infrared light to infer scattering and absorption coefficients, and hence, the presence of structures within tissues. Fluorescence markers, which accumulate in specific regions, can be used to monitor functional and metabolic activity in small animals. These are mostly used to detect tumours, monitor progression of disease, response to therapy, gene expression and protein-protein interactions.
I will talk about two optical imaging modalities: fluorescence diffuse optical tomography (fDOT) and optical projection tomography (OPT). The main issues in fDOT are the ill-posedness of the problem, which requires the use of regularisation techniques, the large data sets and solution spaces and the presence of heterogeneities in the tissues. I will show how nonlinear anisotropic diffusion regularisation that incorporates anatomical information can provide images with higher quality than standard regularisation methods and how the overcome the two other main challenges in fDOT.
Attenuation images are reconstructed from standard OPT measurements. I will show how we can simultaneously reconstruct absorption and scattering maps. Furthermore, in order to reduce acquisition time we reduce the amount of measured data and I will show how images can still be reconstructed from a reduced set of measurements.