CMIC Seminar: Bingham-NODDI - mapping anisotropic orientation dispersion of neurites using diffusion MRI

Speaker: Maira Tariq
UCL Contact: Dominique Drai (Visitors from outside UCL please email in advance).
Date/Time: 25 Nov 15, 13:00 - 14:00
Venue: Roberts106

Abstract

In this talk I will present Bingham-NODDI, a novel method for quantifying complex neurite configurations such as fanning and bending fibres, shown to be widespread in the human brain, using a novel measure of anisotropic dispersion. The proposed model allows a rich characterisation of the orientation distribution of neurites, by distinguishing the anisotropy of orientation dispersion from the overall dispersion. We present the first explicit quantification of this anisotropy, using in vivo diffusion MRI data and provide a thorough analysis of the accuracy and the precision of estimating the key parameters of the model, including the dispersion anisotropy. We obtain plausible in vivo maps of neurite morphology from our model using a clinically feasible protocol.